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diagnosis hematology management lymphoma pathophysiology signs chronic cll differential hodgkins lymphocytic mds myelodysplastic syndrome algorithm alkpos als amyotrophic anaplastic anemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... B-cell lineage ALL Symptoms ... -> AML: Blast crises ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphoblastic Leukemia ... Reed-Sternberg Cells ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Skin: - CLL cells ... smear: Smudge cells ... or basket cells ... diagnosis #workup #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... lymphocytes, smudge cells ... Constitutional symptoms ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... transformation to acute leukemia ... treatment #hematology #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- B symptoms ... involved) • No leukemic ... Nodal disease: B symptoms ... Diagnosis of B-Symptoms ... NonHodgkins #comparison #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... number of CD34+ cells ... virus (EBV) • Leukemia ... • Improve the symptoms ... Aplastic #Anemia #oncology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
commonly hairy-cell leukemia ... Viral replication causes ... vascular endothelial cells ... Diagnosis #Signs #Symptoms
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
variant can have leukemic ... advanced stage + B symptoms ... hof (Hallmark cells ... ) • Donut cells ... than one • Rare cases
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... age 70 years Symptoms ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... diagnosis #hematology #oncology
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