1620 results
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... bruising/bleeding, fatigue ... hepatomegaly • Labs: anemia ... Diagnosis #Algorithm #hematology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Idiopathic • Chronic Fatigue ... Syndrome #Chronic #Fatigue
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Presentation: • Fever • Fatigue ... #oncology #hematology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
• New-onset anemia ... associated weight loss, fatigue ... Electrophoresis #SPEP #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... include fatigue ... • hemolytic anemia ... disease #hemolytic #anemia ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Symptoms: • Fatigue ... blood cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... Syndromes #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
sweats • Extreme fatigue ... • Neutropenia, anemia ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
CML Symptoms: • Fatigue ... - infiltrates (anemia ... Drenching night sweats/fatigue ... #Leukemia #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... #Hemolytic #Anemias ... Diagnosis #Algorithm #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Infiltration: • Hematologic ... and non-hematologic ... Toxins • Aplastic Anemia ... Algorithm #Causes #Hematology