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Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
renal failure Clinical ... hypercalcuria (~40%); fatigue ... post-sarcoidosis fatigue ... syndrome). 30-50% ... arrhythmias, dyspnoea, fatigue
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Conjugation == Gilbert Syndrome ... hyperbilirubinemia syndrome ... autosomal recessive syndrome ... as jaundice on clinical ... abdominal cramps, fatigue
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... ), Depression, Fatigue ... Demyelinating syndromes
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
thyroid, Sjogren syndrome ... Clinical Picture ... - Generalized fatigue ... Diagnosis - Clinical ... Clinical DX: -
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... Presentation: • Fever • Fatigue ... Constitutional Syndromes ... marrow-failure syndromes
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... climbing stairs • Fatigue ... Guillain-Barré syndrome ... antisynthetase syndrome ... IU/I • SAMS clinical
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
Management Summary Clinical ... Weight loss, fatigue ... Budd Chiari syndrome
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... tubule (DCT) Clinical ... Salt craving • Fatigue ... • Bartter syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... sweats • Extreme fatigue ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
Pathogenesis and clinical ... findings - Fatigue ... Acute Coronary Syndrome
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