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management disease differential adultonset aosd infectiousdiseases acidosis activation adult blastomycosis bronchiectasis calcium cardiology cardiomyopathy causes classification conditions cppd deposition erythematosus
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
and progressive fibrosis ... calcinosis • Pulmonary ... : ILD (interstitial ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... solid cancers • Systemic ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... episode (30%) Systemic ... #AdultOnset #Stills ... Disease #AOSD #rheumatology ... #treatment
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
- Summary Antinuclear ... severe disease Treatment ... : • Mild disease ... Erythematosus #SLE #Summary ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Disease Systemic ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... +, Adult-onset Still ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
Bronchiectasis - Summary ... Fevers and/or chills ... Causes: • Cystic fibrosis ... parenchyma Diagnosis ... mycobacteria Treatment
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
infection • Still's ... Wilson's disease Pulmonary ... Spondyloarthropathies, SLE • Pulmonary ... #differential #diagnosis ... #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
the critically ill ... / hypoxemia -> focus ... before beginning treatment ... of Circulatory System ... output - Acute pulmonary
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