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Regulation of GFR Physiologically, GFR is auto-regulated very precisely with changes in the mean arterial pressure (MAP)
Regulation of GFR ... Physiologically, GFR ... Neuro-hormonal feedback #Pathophysiology ... #Nephrology #GFR ... #FiltrationRate
The GFR Clock for Staging CKD Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... Using the GFR clock ... #Nephro #CKD #EGFR
Complications of CKD - Patients with stages 1-3 ([GFR] >30 mL/min) of CKD are generally asymptomatic;
with stages 1-3 ([GFR ... CKD stages 4-5 (GFR ... #Pathophysiology
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... hyperthyroidism ↓ eGFR
To improve the usefulness of the serum creatinine concentration as a marker of kidney function, prediction
accurately predict GFR ... overestimation of GFR ... used to estimate GFR ... CockcroftGault #EGFR
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 Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
Disease (CKD): • GFR ... • AKI, OR • GFR ... • Decrease in GFR ... Disease (NKD): • GFR
Fatality / Mortality Calculations in an Outbreak There are a number of different types of rates, risks,
fatality rate (CFR ... Infection-fatality risk (IFR ... fatality risk (HFR
Summary of dosing recommendations in renal impairment of commonly used hypoglycaemic agents #Diabetes #Diabetic #Medications #Pharmacology #Dosing
Impairment #CKD #Table #GFR
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
: • Liver -> GHR ... • Muscle -> GHR ... Adipose Tissue -> GHR ... endocrinology #pathophysiology
Adjusted Pain Medication Dosing based on GFR #Renal #Dosing #Pain #Pharmacology #Opiates #CKD #Gabapentin #Table
Dosing based on GFR
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