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differential rheumatology symptoms clinical dermatomyositis algorithm lupus management manifestations pathophysiology skin syndrome antimda5 antimda5dm antinxp2 antinxp2dm autoimmune behcet classification color
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
disease (10%) : SLE ... #dermatology #semiology ... #signs #lesions ... #diagnosis #clinical ... manifestations #pathology #lesions
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Petechiae/Purpura - Diagnostic ... Palpable: 1) If lesions ... . 2) When cutaneous ... #Dermatology #Rash ... #Differential #Ddxof
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... or fluid-filled lesions ... Ill-appearing, vital sign ... #Dermatology #Rash ... #Differential #Ddxof
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
response -> Subacute cutaneous ... scaly annular lesions ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... erythematosus #signs ... #symptoms #diagnosis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemic skin lesions ... mucositis - Rash ... aphthous ulcers, cutaneous ... purpura: strong sign ... , and SLE) • Urinalysis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... ) • Cutaneous Lesions ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... diseases, such as SLE ... purpura: Strong sign ... , mucositis • Rash
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis (DM ... -> Heliotrope Rash ... Polymyositis #PM #Diagnosis ... Pathophysiology #Signs ... #Symptoms #Vasculitis
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