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diagnosis hematology causes algorithm hemolytic hypertension secondary management thrombocytosis agglutinin anesthesia anesthesiology cardiac checklist cold disease disorders encephalopathy erythematosus extravascular
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... syndrome (ST-HUS ... Trousseau's • Malignant hypertension ... anemia" • HELLP ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... Extravascular #Causes #differential ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... vasculitis, malignant hypertension ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Valves, AS - HTN ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Diagnosis #hematology
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
Hypertensive Disorders ... And Proteinuria (e.g ... patients • HELLP: Syndrome ... of hemolysis, elevated ... #cardiology #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm Primary (Essential) (95%) - Onset between age
- Differential ... taken at home, work ... excess (Cushing syndrome ... Primary #Secondary #HTN ... #Cardiology #Differential
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... inflammatory disorders (e.g ... Myelodysplastic syndrome
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
- Workup and Differential ... most pts have HTN ... White-coat syndrome ... #Workup #causes ... #Differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... nose, ears, or fingers ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
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