11 results
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Valves, AS - HTN ... Drug-associated, PCH, Evans Syndrome ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Diagnosis Secondary ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... #secondary
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... for workup, including ... blood loss, Acute hemolysis ... Kawasaki, Nephrotic syndrome ... Thrombocytosis #Platelets #Differential
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Primary (Essential) (95%) - Onset between age
Hypertension - Differential ... taken at home, work ... excess (Cushing syndrome ... #HTN #Cardiology ... #Differential #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... #rheumatology #
Hypertensive Disorders of Pregnancy
Chronic Hypertension:
 • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg
 •
unless severe HTN ... patients • HELLP: Syndrome ... of hemolysis, elevated ... #obstetrics #cardiology ... #differential #
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... thrombosis+Pulm HTN ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Causes of Toxic Megacolon - Differential Diagnosis Framework
 • Inflammatory Bowel Disease: Ulcerative colitis, Crohn's colitis
Toxic Megacolon - Differential ... Cryptosporidiosis, Yersinia, Hemolytic-uremic ... syndrome (complicating ... dilatation: 5-HT3 ... Overdistension during radiology