41 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... . mannitol) 3) Loop ... diuretic (e.g. ... Metolazone) 5) Potassium-sparing ... diuretics (e.g.
Flowchart to diuretic use in acute heart failure.

(A) Congestion with volume overload. 

(B) Treatment algorithm after
(B) Treatment algorithm ... Total loop diuretic ... maximal dose for IV loop ... following a single loop ... HeartFailure #Cardiology #Management
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP ... DIURETICS • Furosemide ... Chlorthalidone POTASSIUM-SPARING ... Tolvaptan #Diuretics
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop ... Diuretic Action ... Panel A, loop diuretics ... shown in Panel C, diuretics ... binding to sodium–potassium–chloride
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Pharmacology of diuretics ... Acetazolamide, Loop ... diuretics, MRA, ... HalfLife #Dosing #Loop ... CHF #Cardiology #Management
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... Acetazolamide 2) Osmotic Diuretics ... mannitol) 3) Loop ... Diuretics (e.g. ... HCTZ) 5) Potassium-sparing
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop ... Piretanide Potassium ... nephrology #conversion #loop
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
minutes) Decrease potassium ... Fluids Shift potassium ... renal function) - Loop ... diuretic (often ... #Hyperkalemia #management
Hyponatremia Treatment Algorithm

CHF, Cirrhosis - Fluid restriction
SIADH - Fluid restriction
 - Consider salt tablets if etiology
Hyponatremia Treatment Algorithm ... consider adding loop ... diuretic Reset ... -> free water diuresis ... #Management
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... • HTN Absent: Loop ... and thiazide diuretics ... Differential #Diagnosis #Algorithm ... #causes #potassium