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diagnosis differential anemia activation aplastic bilirubinemia bleeding blood bruising common cvid elevatedmcv essential et extravascular hemeonc hemolysis hemolytic hemophagocytic hlh
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Non-lmmune: • HELLP Syndrome ... Heart Valve) #Thrombocytopenia ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Thrombocytopenia ... Rare • Drugs (e.g ... #Causes #Hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Differential Diagnosis Algorithm ... Sepsis • Drugs (e.g ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... #Causes #Hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... microangiopathy: Thrombotic thrombocytopenic ... Hemolytic uremic syndrome ... differential #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... leukopenia, anemia, and thrombocytopenia ... #Diagnosis #Management ... #Hematology #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... infections/fevers • Thrombocytopenia ... and petechiae Causes ... Anemia #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
specifically immune thrombocytopenia ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... Causes purpura & ... severe thrombocytopenia ... Transfusions #diagnosis #management ... #hematology #reactions
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