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diagnosis differential hematology algorithm causes macrocytosis mcv nutrition pancytopenia workup aafp ascorbicacid atlas bariatric bloodcell bypass calculation elevatedmcv folate folicacid
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Micronutrient Deficiencies ... cardiomyopathy) • Folate ... - Macrocytic anemia ... Vitamin B12 - Macrocytic ... uw_IMresidency #nutrient #Deficiencies
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... MatthewHoMD #Macrocytic ... #Anemia #differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Framework by MCV Microcytic ... Sideroblastic anemia ... Infections Macrocytic ... Megaloblastic: Folate
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... but undiagnosed, folate ... #Macrocytosis #Macrocytic ... #Anemia #VitaminB12 ... #Folate #FolicAcid
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... MCV - <80fL - "Microcytic ... thalassemia • Anemia ... MCV - >96fL - "Macrocytic ... B12 deficiency, Folate
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC Folate ... Rule out B12 and Folate ... Liver Disease #Macrocytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... (sometimes) Macrocytic ... Vitamin B12 or Folate ... iron deficiency anemia ... Autoimmune hemolytic anemia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... deficiency: • B12/folate ... /combined deficiencies
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... inflammation • Nutrient deficiencies ... , Vitamin B12, Folate ... • Hormone deficiencies
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Nutritional Deficiencies ... Vitamin B12 • Folate
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