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Thrombotic Thrombocytopenic Purpura (TTP) vs Disseminated Intravascular Coagulation (DIC)
#Diagnosis #TTP #DIC #Comparison #Table #Laboratory #Findings #RebelEM
Thrombotic Thrombocytopenic ... Purpura (TTP) vs ... Intravascular Coagulation ... Findings #RebelEM #Thrombocytopenia
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Platelet defects • Coagulation ... Primary Causes: - Thrombocytopenia ... Kasabach-Merritt syndrome Coagulation
Algorithm for the outpatient management of thrombocytopenia. 
(DIC = disseminated intravascular coagulation; EDTA = ethylenediaminetetraacetic acid;
management of thrombocytopenia ... intravascular coagulation ... purpura; TTP = ... thrombotic thrombocytopenic ... purpura.)
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
purpura (ITP) ... • Thrombotic thrombocytopenic ... purpura (TTP) ... intravascular coagulation ... (DIC) • Anti-coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... DITMA) - MAHA + Thrombocytopenia ... coagulopathy - Thrombocytopenia
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... BrighamChiefs #Purpura
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
• Thrombotic Thrombocytopenic ... Purpura (TTP) ... Metabolism-mediated TMA - Coagulation-mediated
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
Causes of Purpura ... purpura ... intravascular coagulation ... Henoch—Schönlein purpura ... - Scurvy #Purpura
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Wet purpura is the ... individuals with thrombocytopenia ... are typical of coagulation ... Measurement of coagulation ... Bruise #ecchymosis #thrombocytopenia
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
usually also have thrombocytopenia ... intravascular coagulation ... and thrombotic thrombocytopenic ... purpura.