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diagnosis hematology causes acidosis classification elevatedmcv lactate lactic macrocytosis workup approach criticalcare deficiency dm2 false folicacid hba1c hemolytic hgba1c hyperferritinemia
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... Reduction == Increase ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis ... #DM2 #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • B12/Folate ... Classification #Approach #Differential ... #Diagnosis #Algorithm
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Diagnosis Algorithm ... Decreased WBCs ... - Decreased/NormaI ... Infiltration - Increased
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... in this era • Increased ... have hemolytic anemia ... anticonvulsants lead to increase ... deficiency #FolicAcid #differential
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... #elevatedMCV #Differential ... #Diagnosis #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Decreased Megakaryopoiesis ... • Aplastic Anemia ... Deficiency • Folate ... Deficiency • Folate
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Malabsorption • Increased ... Rule out B12 and Folate ... #Diagnosis #Algorithm
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Increased hepcidin ... Decreased hepcidin ... levels will cause increased ... Sideroblastic anemia ... extreme ferritin elevation
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... without platelet decrease ... #Differential #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... immune hemolytic anemia ... Mild-to-moderate elevation ... WBC count and differential
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