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diagnosis hematology classification elevatedmcv macrocytosis acidosis approach deficiency dm2 false folicacid hba1c hgba1c hyperferritinemia laboratory lactate lactic macrocytic microcytic normocytic
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Iron, B-12, or folate ... Reduction == Increase ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • B12/Folate ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Diagnosis Algorithm ... Decreased WBCs ... - Decreased/NormaI ... Infiltration - Increased
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... #elevatedMCV #Differential ... #Diagnosis #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... Decreased Megakaryopoiesis ... • Aplastic Anemia
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... have hemolytic anemia ... that can cause ... anticonvulsants lead to increase ... deficiency #FolicAcid #differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Malabsorption • Increased ... #Causes #Hematology
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Increased hepcidin ... Decreased hepcidin ... increased GI absorption ... Sideroblastic anemia ... extreme ferritin elevation
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... immune hemolytic anemia ... Mild-to-moderate elevation ... WBC count and differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... Circulatory System • Increased ... muscle use • Decreased ... 30mmHg) - Severe anemia ... #Differential #
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