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diagnosis differential causes elevatedmcv macrocytosis workup approach classification deficiency dm2 false folicacid hba1c hemolytic hgba1c hyperferritinemia laboratory macrocytic mentzerindex microcytic
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... Reduction == Increase ... • Hemolytic anemia ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... combination of: Decreased ... Deficiency • B12/Folate ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Differential Diagnosis Algorithm ... Decreased WBCs ... - Decreased/NormaI ... Infiltration - Increased ... #Causes #Hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... in this era • Increased ... have hemolytic anemia ... anticonvulsants lead to increase ... differential #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Decreased Megakaryopoiesis ... • Aplastic Anemia ... Deficiency • Folate ... Deficiency • Folate ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Differential Diagnosis Algorithm ... TlBC > 18% • Anemia ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... Neutrophils - Low RBC Folate ... Malabsorption • Increased ... Rule out B12 and Folate ... #Causes #Hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Anemia is described ... Pancytopenia is a hematologic ... characterized by a decrease ... involves disorders of increased
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... without platelet decrease ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... immune hemolytic anemia ... Mild-to-moderate elevation ... Diagnosis #Workup #Hematology
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