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diagnosis hepatology algorithm causes lfts transaminitis hepatitis hematology management abnormal acidosis alkaline alp cardiology disease enzymes fever gastroenterology infectiousdiseases laboratory
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... Syndrome (Hemolysis, Elevated ... to 10-20-fold elevation ... hepatitis #comparison #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... #Differential #
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... Injury • AST/ALT elevation ... Transaminitis #diagnosis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... specificity to elevated ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... Failure - Elevated ... synthesis - Elevated ... ALT and AST - Elevations ... fold with acute liver
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Transaminitis - Differential ... Trauma: Shock liver ... Transaminitis #Elevated ... Transaminases #hepatitis #Differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - Differential ... (Drug-induced liver ... LouLectures #Liver ... #Tests #LFTs #Differential
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... is made in the liver ... saturation to differentiate ... inflammatory causes of elevated ... extreme ferritin elevation
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