11 results
diagnosis hematology hepatology liver lfts causes hemolytic hepatitis workup aflp anemia anemias chemistry comparison dehydrogenase disease elevated extravascular icp injury
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Reticulocytes • Abnormal ... Membrane defects, Enzyme ... #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... elliptocytosis - RBC Enzyme ... #Diagnosis #Algorithm
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... Syndrome (Hemolysis ... Elevated Liver enzymes ... hepatitis #comparison #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... deficiency, Other enzyme ... thrombocytopenia - DIC, TTP, HELLP ... #Anemia #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... TTP, HUS, DIC, HELLP ... , Spiders - Enzyme ... Blood Smear ↑ abnormal ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... a cytoplasmic enzyme ... upon damage • Normal ... red blood cell enzymes ... Idiosyncratic LDH Elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... • Pregnancy: HELLP ... function may be abnormal ... Source of Liver Enzyme
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... Pregnancy - AFLP, HELLP ... disease US — Normal
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... levels - Usually normal ... products or D-dimer - Normal ... Mild-to-moderate elevation ... WBC count and differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... or amyloid: • Elevation ... Source of Liver Enzyme ... Elevation: • ... chemistry #diagnosis #differential
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