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diagnosis hematology hepatology liver lfts causes hemolysis hepatitis workup aflp anemia anemias chemistry comparison dehydrogenase disease elevated extravascular icp injury
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Reticulocytes • Abnormal ... Membrane defects, Enzyme ... #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... elliptocytosis - RBC Enzyme ... #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... deficiency, Other enzyme ... thrombocytopenia - DIC, TTP, HELLP ... #Anemia #Differential
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... Syndrome (Hemolysis ... Elevated Liver enzymes ... hepatitis #comparison #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... TTP, HUS, DIC, HELLP ... , Spiders - Enzyme ... Blood Smear ↑ abnormal ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... a cytoplasmic enzyme ... upon damage • Normal ... red blood cell enzymes ... Idiosyncratic LDH Elevation
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... Pregnancy - AFLP, HELLP ... disease US — Normal
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... • Pregnancy: HELLP ... Source of Liver Enzyme ... Elevation: •
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... levels - Usually normal ... products or D-dimer - Normal ... Mild-to-moderate elevation ... WBC count and differential
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... the magnitude of enzyme ... elevation and clinical ... #Liver #Enzymes ... #Differential #
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