14 results
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
== Decreased RBC ... • Asplenia Laboratory ... HbA1c #HgbA1c #Laboratory ... #Diagnosis #DM2 ... #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity is the diagnostic ... Mild-to-moderate elevation ... WBC count and differential ... #Workup #Hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
or normal) • Elevation ... : Elevated • Decreases ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... Hyperferritinemia, decreased ... fraction < 20% Differential ... Diaqnoses: • ... management #treatment #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Diagnosis Algorithm ... without platelet decrease ... bartonella (oroya fever ... #workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Fragility: • Decreased ... mountain spotted fever ... #Diagnosis #hematology ... #rheumatology #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... myocarditis, rheumatic fever ... Idiosyncratic LDH Elevation ... #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... Diagnosis The ... - assess other laboratory ... muscle use • Decreased ... #Differential #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Diagnosis Framework ... Muscle swelling - Fever ... ULN • AST/ALT Elevation ... vasoconstriction → decreased
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
Dermatomyositis • Fever ... no significant elevation ... ILD worsens Decreased ... Dermatomyositis #rheumatology ... #dermatology #diagnosis