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diagnosis hepatology lfts differential laboratory tests bilirubin chemistry function interpretation transaminitis abnormal alkphos alp astalt enzymes gastroenterology hepatitis hyperbilirubinemia injury
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Liver Function Tests ... aminotransferase (ALT) - Alkaline ... (Indirect) ... - Conjugated (Direct ... Prothrombin #Liver
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... vs bone Bili - Direct ... Transaminase >> Alkaline ... #FunctionTest # ... LFTs #Elevation
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
, lungs, RBCs Alkaline ... bilirubin (TBili) Direct ... bilirubin (Conjugated ... Indirect bilirubin ... (Unconjugated)
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct ... Differential #Diagnosis #Algorithm
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Tests - AST, ALT, Alkaline ... Alkaline phosphatase ... hepatocyte - Elevation ... cytochromes) • Unconjugated ... MRP2 transports conjugated
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Differential #Diagnosis #Algorithm
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... LFTs #Abnormal #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... life: 1 week • Direct ... or amyloid: • Elevation ... Enzyme Elevation ... blood cells Unconjugated
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Bilirubin - +/- elevation ... Half-life: 1 week • Direct ... injury: ~ 1 Unconjugated ... Enzyme Elevation
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