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diagnosis differential hepatology algorithm alkaline alp infectiousdiseases lfts phosphatase transaminitis acidosis acute antimda5 antimda5dm bilirubin cholestatic classification conjugated dermatology dermatomyositis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic Liver ... Hepatocellular Liver ... Injury • AST/ALT elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... of elevation:
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... is made in the liver ... Most Common Causes ... 1% Most Common Causes ... extreme ferritin elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... Bilirubin - +/- elevation ... Enzyme Elevation
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... glucose by the liver ... contribution of liver ... Elevation Type ... Lactic #Acidosis #Elevation
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Muscles, Kidneys, Liver ... Rhabdomyolysis - AKI - Liver ... tissue damage (AKI, Liver ... acidosis - CPK elevation ... differential #diagnosis #causes
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... Most cases diagnosed ... Phosphatase: • Other causes ... eliminated • Elevation ... phosphate &/or • Elevation
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
no significant elevation ... disease and ILD • Liver ... Liver biopsies show ... Women • ~20% of cases ... Men • ~50% of cases
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