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diagnosis differential hematology prolonged aptt bruising hepatology anemia blanching bruise chemistry classification dic disorders disseminated ecchymosis genital gynecology hematomas hemostasis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PT (INR) - Bleeding ... PT (INR) - No Bleeding ... Differential #Diagnosis #Algorithm ... #coagulation #disorders
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Destruction • Abnormal ... Iatrogenic) • Liver ... #Causes #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... ) ABNORMAL PT ... PT/ABNORMAL PTT ... discern these causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... Treat primary cause ... #diagnosis #causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Pre-analytical cause ... Reduced liver synthesis ... Jcortesizaguirr #Abnormal
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... • Reduced liver ... amyloidosis #Abnormal ... differential #hematology #coagulation
Causes of Abnormal Genital Bleeding - Differential Diagnosis Algorithm Non-Gynecologic: • Medical (e.g. coagulopathy, liver disease, renal
Causes of Abnormal ... Genital Bleeding ... Differential Diagnosis Algorithm ... coagulopathy, liver ... #Causes #OBGyn
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Chronic Disease Normal ... 80-100 fL) • Bleeding ... Renal Disease, Liver ... #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Albumin • Coagulation ... factors: PT/INR ... of ALP • Near normal ... RBC (hemolysis, bleeding
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... levels tend to be normal ... , PT should be normal ... Measurement of coagulation
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