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diagnosis differential hematology hepatology aptt bleeding bruising lfts prolonged pt transaminitis bilirubin chemistry conjugated gastroenterology hemostasis hepatitis hyperbilirubinemia injury interpretation
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... vs bone Bili - Direct ... #FunctionTest # ... LFTs #Elevation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Destruction • Abnormal ... Iatrogenic) • Liver ... #Causes #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Pre-analytical cause ... Reduced liver synthesis ... Jcortesizaguirr #Abnormal
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... Drugs: Direct or ... • Reduced liver ... amyloidosis #Abnormal ... differential #hematology #coagulation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... life: 1 week • Direct ... • Albumin • Coagulation ... or amyloid: • Elevation ... Enzyme Elevation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... dabigatran, argatroban, direct ... intravascular coagulation ... discern these causes ... Anticoagulants (warfarin, direct
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Bilirubin - +/- elevation ... Half-life: 1 week • Direct ... Enzyme Elevation
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