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diagnosis hepatology anemia hematology acidosis cancer dili disorders drug elevation gastroenterology hemolytic hepatomegaly hyponatremia idiosyncratic injury lactate lactic liverenzymes management
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... #DILI #Drug #induced ... Idiosyncratic #differential ... gastroenterology #algorithm
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... : • Liver disease ... warm, cold, drug induced ... Hemolytic #Anemia #Differential ... #classification
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Others #LFTs ... #Causes
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... #Anemia #MCV #Classification ... #Differential #
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Hepatitis • Drug Induced ... #Causes #Hepatology
Causes of Tremors - Movement Disorders - Differential Diagnosis Algorithm Action Tremor - Occurs During Voluntary Muscle
Causes of Tremors ... Diagnosis Algorithm ... Atrophy • Drug-induced ... Etiology (Thyroid, Liver ... #Causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... glucose by the liver ... contribution of liver ... Acidosis #Elevation #Differential ... #typea #typeb #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... • Hydralazine-Induced ... Tests: • CBC • LFT ... polyarteritis, drug-induced ... #rheumatology #classification
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Hyponatremia Differential ... Diagnosis Algorithm ... amyloidosis) • Liver ... chemotherapy, nausea ... #Hyponatremia #Differential
Oral / Mouth Lesions and Ulcers (Adult & Elderly) - Differential Diagnosis Algorithm Teeth • GERD (Dissolves
Adult & Elderly) - Differential ... Diagnosis Algorithm ... Sarcoidosis • Drug Induced ... Change • Chronic Liver ... #Causes
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