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diagnosis differential hepatology hematology gastroenterology injury lfts management transaminitis abnormal acute aptt ascites bilirubin bleeding bruising classification coagulation fever hyperbilirubinemia
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... vs bone Bili - Direct ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... DDX of Hepatic
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic Liver ... Injury • AST/ALT elevation ... more specific for hepatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Injury: • Hepatic ... Half-life: 1 week • Direct ... Enzyme Elevation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... Drugs: Direct or ... drugs (e.g. direct ... thrombin inhibitors, heparin ... • Reduced liver
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Direct Xa inhibitors ... Direct or indirect ... Reduced liver synthesis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... Differential #Diagnosis #Causes ... #Acute #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... life: 1 week • Direct ... replaced by non-hepatic ... or amyloid: • Elevation ... Enzyme Elevation
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... Differential Diagnosis Algorithm ... Hypertension - Hepatic ... disease • Acute liver ... #Hepatology #causes
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