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diagnosis differential hepatology bruising gastroenterology hematology lfts management transaminitis alkaline alp amyloid amyloidosis ascites bilirubin bleed chemistry classification conjugated encephalopathy
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... vs bone Bili - Direct ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... DDX of Hepatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Injury: • Hepatic ... Half-life: 1 week • Direct ... RBC (hemolysis, bleeding
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Iatrogenic) • Liver ... Coagulation #Bleeding ... #Causes #Hematology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct
Upper GI Bleed - Management Algorithm Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR Initial Stabilization Concern for
Bleed - Management Algorithm ... Consult GI ± EGD Causes ... GI Bleed: • Peptic ... Disease • Variceal Bleeding ... GAVE (idiopathic, liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... life: 1 week • Direct ... replaced by non-hepatic ... Enzyme Elevation ... RBC (hemolysis, bleeding
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... dabigatran, argatroban, direct ... discern these causes ... are liver function ... Anticoagulants (warfarin, direct
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
Hepatic Encephalopathy ... by liver insufficiency ... rule out other causes ... Infection, GI bleeding ... data is limited Diet
Common Malignancies That Cause Ascites The most common malignancies causing ascites are ovarian cancer, pancreatic cancer, gastric
Malignancies That Cause ... - Most common cause ... is peritoneal seeding ... hypertension or hepatic ... obstruction or direct
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