13 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... PT (INR) - Bleeding ... PT (INR) - No Bleeding ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... ) ABNORMAL PT ... PT/ABNORMAL PTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... Treat primary cause ... Coagulation #diagnosis #causes
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... e.g. heparin ... Reduced liver synthesis ... Jcortesizaguirr #Abnormal
Upper GI Bleed - Management Algorithm

Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR
Initial Stabilization
Concern for
Bleed - Management Algorithm ... Consult GI ± EGD Causes ... GI Bleed: • Peptic ... Disease • Variceal Bleeding ... GAVE (idiopathic, liver
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Destruction • Abnormal ... Iatrogenic) • Liver ... #Causes #Hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... amyloidosis #Abnormal
Causes of Abnormal Genital Bleeding - Differential Diagnosis Algorithm
Non-Gynecologic:
 • Medical (e.g. coagulopathy, liver disease, renal
Causes of Abnormal ... Genital Bleeding ... Differential Diagnosis Algorithm ... coagulopathy, liver ... #Causes #OBGyn
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Chronic Disease Normal ... 80-100 fL) • Bleeding ... Renal Disease, Liver ... #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... RBC (hemolysis, bleeding