9 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... SinaiBmoreIMRes #Liver #FunctionTest ... #Transaminitis ... #diagnosis #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... LouLectures #Liver #Function ... Differential #Diagnosis #hepatology ... #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... kwburak #LFTs #Elevated ... #Abnormal #Transaminitis ... Algorithm #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
specificity to elevated ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... #differential #Hepatology ... #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
specificity to elevated ... Bilirubin - +/- elevation ... Tests of synthetic function ... of Liver Enzyme Elevation ... diagnosis #algorithm #hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
severe mobility/functional ... intracranial pressure - Elevated ... eliminated • Elevation ... phosphate &/or • Elevation ... Hyophosphatasia #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009

At least three of the following: 
 -
following: - Fever ... - Ferritin elevation ... - Elevated soluble ... Diagnosis #Criteria #Hematology
Fever After International Travel

Infectious Disease:
• Endemic in either the destination or home region

Viral Syndromes:
Arboviral infections, a
Fever After International ... thrombocytopenia, and elevated ... • Yellow fever ... febrile illness, elevations ... liver and renal function
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hyperferritinemia - Elevated ... Impaired cytotoxic function ... Fever b. ... Elevated soluble ... Diagnosis #Management #Hematology