38 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
cytokine synthesis, e.g ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: when any egg ... Neurological Compromise (e.g ... Cardiac Compromise (e.g ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Lipid mediators (e.g ... Other mediators (e.g ... inflammatory mediators (e.g ... #Anaphylaxis #pathophysiology ... #immunology
Innate Immune Cells - Pathophysiology
The innate immune system consists of granulocytes, mast cells, natural killer cells,
Immune Cells - Pathophysiology ... carry out defence functions ... Immune #Cells #Pathophysiology ... #immunology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... anticoagulant (e.g ... : Inhibits the function ... heparin (LMWH): Functions ... #Pharmacology #Pathophysiology
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Decreased ENaC channel function ... Aldosterone Receptor Function ... #Hyperkalemia #Pathophysiology ... #Pharmacology #
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... Action #nephrology #pharmacology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
chromosome -> Impaired function ... Impaired B cell function ... bacterial infections (e.g ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Endocarditis checklist
Initial evaluation
 • Peripheral blood cultures (three sets at three different sites)
 • Additional culture
if suspected (e.g ... block (+/- daily EKG ... worsening valve function ... of infection (e.g ... Endocarditis #checklist #criticalcare
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
antagonist use (e.g ... adjunct therapy) e.g ... adjunct therapy) e.g ... Treatments #Management #pathophysiology ... #immunology