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hematology causes management signs symptoms antinuclear classification erythematosus algorithm antibodies autoantibodies pericarditis sle associations bruising cardiology comparison dermatology disease hemolytic
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... to cold IgG • Lupus ... #Monoclonal #Differential ... #Diagnosis #Oncology
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
C viruses. systemic ... lupus erythematosus ... syndrome • IgA ... #vasculitis #differential ... #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... lupus erythematosus ... SLE), Sjogren's Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
ANA (anti-nuclear ... • Scleroderma (Systemic ... Vasculitis: P-ANCA ... #diagnosis #associations ... #table
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS) - Differential ... capillary leak syndrome ... • Schnitzler syndrome ... #Diagnosis #hematology ... #oncology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
central nervous system ... lupus erythematosus ... #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Autoimmune Diseases: • Systemic ... lupus erythematosus ... #Diagnosis #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... Diagnosis: Systemic ... LFT • ESR • ANA ... differential #diagnosis ... #rheumatology #
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Diagnosis for Pulmonary ... Immune Complex: Systemic ... lupus erythematosus ... , anti-GBM ab, ANA ... #differential #
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