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sle systemic classification comparison differential hematology vasculitis activation ana antinuclear autoantibodies cerebritis champs cns complement cryoglobulinemia cryoglobulins diseases druginduced glomerular
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... #SLE #CNS #neurology ... #rheumatology # ... #management #treatment
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... #Erythematosus ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
antiphospholipid syndrome ... S - Systemic Lupus ... Erythematosus ( ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... (e.g. systemic lupus ... erythematosus ( ... Cryoglobulins #diagnosis ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... SJIA], systemic lupus ... erythematosus [ ... #Diagnosis #Management ... #Hematology #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Farr assay) and lupus ... SLE-SSc-AlM overlap syndromes ... #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
/nephritis • Lupus ... Post-infectious GN ... glomerular #diseases #nephrology ... pathology #comparison #table ... #diagnosis #microscopy
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Erythematosus ( ... Usual therapeutic management ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... erythematosus, ... #rheumatology #
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