26 results
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... purpura/hemolytic ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... pylori test (GI symptoms ... #Diagnosis #Causes ... #Workup #hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Neurological 12% - Thrombocytopenia ... Lymphadenopathies 7% - Hemolytic ... Diagnosis and Lupus ... autoantibodies #signs #symptoms ... #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Schistocytes, thrombocytopenia ... #Anemia #Differential ... #workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential ... Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Serum Sickness Hemolytic ... #Causes #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... #diagnosis #algorithm ... #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... activity is the diagnostic ... available for rapid diagnosis ... WBC count and differential ... #Workup #Hematology