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differential management sle erythematosus systemic approach disease druginduced hematology joint msk signs table vasculitis agglutinin allergy ana anemia antinuclear autoantibodies
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
• Arthritis domain ... Thrombocytopenia, Autoimmune hemolysis ... Highly specific antibodies ... Erythematosus #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
: - Arthritis ... Lymphadenopathies 7% - Hemolytic ... SLE-Related Auto-Antibodies ... autoantibodies #signs #symptoms ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... of hip (rare), Arthritis ... lesions Abdominal pain ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... context of other symptoms ... ANA #patterns #rheumatology ... #diagnosis #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... Diagnosis: • hemolytic ... chills, flank pain ... #anemia #hematology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
Approach to Joint Pain ... or nerve root Symptoms ... #MSK #rheumatology ... #approach #workup ... #differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... : • Joint pain ... : • Symptoms limited ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... , Arthritis, myalgia ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... Presentation - Systemic Symptoms ... C-ANCA) pattern: antibodies ... #rheumatology # ... classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... types or during hemolytic ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... Pathophysiology #Allergy #Diagnosis
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