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sle erythematosus systemic management allergy differential druginduced hypersensitivity reactions signs table vasculitis allergic autoantibodies comparison criteria cryoglobulinemia cryoglobulins definitions dil
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
thrombocytopenia, Autoimmune Hemolytic ... • Ex: Systemic Lupus ... Erythematosus, Reactive Arthritis ... #Classification ... #Diagnosis #Definitions
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... • Arthritis domain ... Thrombocytopenia, Autoimmune hemolysis ... Erythematosus #diagnosis ... #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
or during hemolytic ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... #Classification ... Pathophysiology #Allergy #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... : - Arthritis ... Lymphadenopathies 7% - Hemolytic ... autoantibodies #signs #symptoms ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... of hip (rare), Arthritis ... Thrombocytopenia #Lupus ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthralgia, and arthritis ... Labs/Diagnosis: ... (e.g. systemic lupus ... #types #classification ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... , Arthritis, myalgia ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... Kikuchi disease • Type-I ... : • Symptoms limited ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... such as systemic lupus ... Presentation - Systemic Symptoms ... #rheumatology # ... classification
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... Tests for All Types ... #laboratory #workup ... #Rheumatology
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