12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... , Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... immune system, leading ... (e.g. systemic lupus ... classification #rheumatology ... #vasculitis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
& Cryoglobulinemic ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... ANCA +MPO) • Cryoglobulinemic ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... Med, Contrast, Pigment ... nephrology #causes #algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... • Steroids • Vasculitis ... Coagulation #Bleeding ... #Causes #Hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Rapidly progressing GN ... • Pauci immune GN ... , pauci-immune GN ... / ANCA + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Differential Diagnosis Algorithm ... • Systemic Lupus ... Leukemia - History of Bleeding ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
Kaposi's sarcoma • Rheumatologic ... Autoimmune: ANCA-Assoc vasculitis ... > EGPA, MPA), Cryoglobulinemia ... Nasopharyngeal bleeding
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Paradoxical spontaneous bleeding ... malignancies, vasculitis ... , sepsis or cryoglobulinemia ... Calciphylaxis • Cryoglobulinemia ... Cryofibrinogenemia #diagnosis #rheumatology