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hematology syndrome differential treatment vasculitis activation anemia aplastic behcet cerebritis classification coagulation dermatology dic disseminated erythematosus intravascular macrophage mas mds
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... #Differential #Diagnosis ... #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... autoantibodies that will cause ... #neurology #rheumatology ... #management #treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : Blast crises ... #Hematology #Oncology ... #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... nervous system (CNS ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... tears, Ischemia, Leukemia ... Reactive Arthritis, AS ... #management #signs ... #symptoms #rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Causes: - Idiopathic ... ’s syndrome - Lupus ... Diagnosis: ... #dermatology #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... tract, and often causes ... chorioretinitis, CNS ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • 8%-27% for CNS ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... Thromboembolism (7%) • CNS ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
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