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hematology differential treatment ams anemia aplastic cerebritis emergencies encephalopathy erythematosus hemeonc hypertension mds monoclonal myelodysplastic neurology oncologic paraproteinemias sjogrens sle
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
Hypertension and Altered ... - Differential Diagnosis ... Renal: • Acute GN ... Vasculitis • Lupus ... #causes
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... transformation to acute leukemia ... Myelodysplastic #Syndrome ... #hematology #oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... #neurology #rheumatology ... #management #treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... : CNS manifestations ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Treat underlying cause ... Usually myeloid leukemias ... ) - Symptoms: CNS ... post-infusion) - ICANS: altered ... #HemeOnc #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... Hypocomplementemia • Can cause ... Membranoproliferative GN ... #Rheumatology # ... Diagnosis #Management
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