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differential hematology cerebritis dic disseminated emergencies erythematosus hemeonc intravascular monoclonal neurology oncologic paraproteinemias prs pulmonary sjogrens sle syndrome syndromes systemic
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... to cold IgG • Lupus ... vascular beds-renal ... #Differential #Diagnosis ... #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... permeability Diagnosis ... #neurology #rheumatology ... #management #treatment
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Bleeding (64%) • Renal ... Thromboembolism (7%) • CNS ... #diagnosis #causes ... #treatment #management ... #hematology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
recent DAN) • EMG/NCS ... Goodpasture's cause ... hematuria, RBC casts ... in crescentic GN ... #management #treatment
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
intravascular coagulation ... Treat underlying cause ... ) - Symptoms: CNS ... , hypotension, renal ... #HemeOnc #Diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Distal (Type I) renal ... Membranoproliferative GN ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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