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diagnosis differential classification hematology algorithm ana anca antibodies antibody antineutrophil antinuclear cryoglobulinemia cryoglobulins diffuse diseases erythematosus lymphadenopathy management monoclonal paraproteinemias
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lupus Erythematosus ... Leukemia - History of Bleeding ... Lymphadenopathy #LAD ... #Hematology #Oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Autoantibodies: • WAIHA • CAD ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... lupus erythematosus ... retinopathy Lab ... differential #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... drug-induced SLE) • Systemic ... Anti-La/SSB • ... antibodies #diagnosis #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... 3) Limb oedema leading ... diagnosis #sle #clues ... #system #erythematosus ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
, leading to the ... • They can cause ... Cryoglobulins Cause ... lupus erythematosus ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... ) • Cutaneous vasculitis ... Membranoproliferative GN ... Vasculitis: • ... Sjogrens #Syndrome #Rheumatology
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