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diagnosis differential erythematosus sle vasculitis systemic algorithm causes management oncology syndrome activation approach arthritis autoantibodies autoinflammatory cryoglobulinemia cryoglobulins e1 eularacr
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Erythematosus Clinical and ... NEUROLOGIC - HEMOLYTIC ANEMIA ... - ANA level above ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... drugs, malignomas, and ... - systemic lupus ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Inflammatory and ... : • Systemic lupus ... Differential #Diagnosis #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... diagnosis #algorithm #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... Auto-Antibodies: - ANA ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #differential #rheumatology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Chronic Bleed - Any ... Disease • Marrow ... #Classification ... Algorithm #Causes #Hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... , Copper and lead ... differential #diagnosis #hematology ... #anemia
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