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diagnosis table ana antinuclear erythematosus sle systemic algorithm associations myopathies myopathy myositis patterns signs symptoms vasculitis autoimmune causes classification connectivetissuediseases
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... Lupus (SLE): ANA ... others (RNP, aPL antibodies ... #Rheumatology #
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
SLE-Related Auto-Antibodies ... (aPL) 30-45% Differential ... Erythematosus #Diagnosis #autoantibodies ... symptoms #mimickers #differential ... #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
to 50X ULN • Autoantibodies ... to 50X ULN • Autoantibodies ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
-C3 GN • Cast ... macular Vasculitis) Autoantibodies ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Farr assay) and lupus ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SLE : systemic lupus ... CTILD #Diagnosis #Differential ... #Comparison #Table ... #Pulmonary #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Drug Induced Lupus ... months) and of autoantibodies ... #sle #comparison ... #table #rheumatology
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