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diagnosis hematology algorithm dermatology purpura autoantibodies bruising classification disorders erythematosus extravascular hemolysis hemolytic intravascular mimickers nonpalpable palpable pediatrics peds petechiae
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... involvement 3% SLE-Related ... Lupusreference #SLE ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Platelet Disorders - Differential ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : - Thrombocytopenia ... - Hemolytic anemia ... Associated - SLE ... #rheumatology #
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... ) - SLE ( ... systemic lupus erythematosus ... Purpura #Bruising #Causes ... pediatrics #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #differential # ... #anemia
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... hemostasis: - Thrombocytopenia ... Autoimmune Vasculitis (lupus ... Measurement of antinuclear ... #dermatology #physicalexam
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... such as systemic lupus ... vasculitis, and SLE ... #diagnosis #rheumatology
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