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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... #nephritis #classification ... #types #rheumatology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Secondary GNs: Due to systemic ... disease or drugs ... , Lupus Acute Tubular ... Interstitial Nephritis ... Differential #Diagnosis #nephrology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Arthritis R Renal ... Disease (Nephritis ... IMDAMNSHARP #sle #systemic ... #rheumatology #
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... , Acute cutaneous ... hemolysis • Renal ... nephritis, Class ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: • Acute ... Non-autoimmune rheumatologic ... Pleural effusions • Acute ... APLA/LAC: • Renal
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
at least 50% Renal ... Drugs • Emboli Systemic ... Interstitial Nephritis ... Sjögren) Post-Renal ... #KidneyInjury #Nephrology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... vascular beds-renal ... Paraproteinemias #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... pulmonary and renal ... lupus erythematosus ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
cirrhosis: 3%-20% Renal ... • Interstitial nephritis ... Distal (Type I) renal ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
Secondary Causes of Hyperlipidemia
Nunerous secondary causes of hyperlipidemia exist; screening for the presence of these underlying
mellitus, Chronic renal ... Glycogen storage disease ... hepatitis, Systemic ... lupus erythematosus ... Hypothyroidism, Nephrotic