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management differential druginduced erythematosus summary syndrome systemic activation algorithm classification cns comparison hematology hemophagocytic hlh lymphohistiocytosis macrophage mas neurology proteinuria
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
autoantibodies that will cause ... of Lupus Cerebritis ... #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... Lupus (DIL): ... cases, drug-dependent ... , SCLE-DIL (terbinafine
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... syndrome • Drugs ... (MPA) • SLE ... Post-infectious GN ... #Proteinuria #Nephrology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... versus DIL • ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... cases, drug-dependent ... , SCLE-DIL (terbinafine ... #DIL #rheumatology ... #diagnosis #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Autoimmune diseases: SLE ... immune deficiency, Drugs ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... such as systemic lupus ... vasculitis, and SLE ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Membranoproliferative GN ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
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