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diagnosis erythematosus systemic differential management vasculitis autoantibodies criteria eularacr glomerulonephritis imdamnsharp mnemonic nephrology progressive rapidly rpgn sjogrens syndrome table treatment
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Antibody (ANA) ... Renal Disease (Nephritis ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... lupus nephritis ... erythematosus #diagnosis #rheumatology ... #table #ANA
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... nephritis, Class ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Erythematosus #Diagnosis #Rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Nephritis Lupus ... in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... treatment #management #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... (C-ANCA): GPA > ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... such as systemic lupus ... SLE) • Urinalysis ... differential #diagnosis #rheumatology ... #classification
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... • Interstitial nephritis ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
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