13 results
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Approach to managing Glomerulonephritis ... (GN) in children ... cytoplasmic antibodies; SLE ... , systemic lupus ... #Glomerulonephritis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... Complement: Post-strep GN ... , Lupus Nephritis ... Kidney: Anti-GBM Glomerulonephritis ... diagnosis #algorithm #rheumatology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
: Pathogenesis and ... : • Systemic Lupus ... Erythematosus (SLE ... Post-infectious glomerulonephritis ... HypersensitivityReaction #Allergy
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Rapidly Progressive Glomerulonephritis ... IgA nephropathy, lupus ... post-infectious GN ... staining #Glomerulonephritis ... #RPGN #Classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... low C4, Low C3 and ... #EULARACR #Classification ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... Post-streptococcal glomerulonephritis ... systemic lupus ... Hypersensitivity #Types #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... LFT • ESR • ANA ... SLE) • Urinalysis ... differential #diagnosis #rheumatology ... #classification
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Nephritis Lupus ... in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... treatment #management #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Serositis Labs: • ANA ... Erythematosus #Diagnosis #Rheumatology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... reactions #types #allergy ... #table #classification