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diagnosis differential algorithm joint sle classification dermatology management systemic aortitis approach cardiology comparison cryoglobulinemia cryoglobulins dermatologic druginduced glomerulonephritis granulomatosis inflammatory
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Polyarteritis Nodosa (PAN ... ANCA associated vasculitis ... (RA), Systemic lupus ... erythematosus ( ... Differential #Diagnosis #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Sarcoidosis • GPA ... lesions • Discoid lupus ... erythematosus ... dermatology #joint #pain ... differential #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... > PR3 60% • GPA ... tract, and often causes ... erythematosus, ... differential #diagnosis #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Inflammatory Joint Pain ... • Systemic Lupus ... Erythematosus ... Inflammatory #JointPain #MSK ... #Orthopedics #Causes
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... burning sensation or pain ... • Ulcerated, erythematous ... • Giant cell arteritis ... rash #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
ischemia • Skin: Erythematous ... MPO > PR3 60/ GPA ... tract, and often causes ... involvement, abdominal pain ... Differential #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... : • Joint pain ... • Mesenteric vasculitis ... #Diagnosis #Rheumatology
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
• Rheumatoid arthritis ... • Systemic lupus ... erythematosus ... connective tissue disease ... spondyloarthropathies • Vasculitis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... lesions Abdominal pain ... (20%) Renal disease ... SLE #systemic #erythematosus
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