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diagnosis differential management erythematosus joint syndrome systemic symptoms antinuclear hematology msk patterns vasculitis workup activation aortitis approach autoantibodies autoimmune behcet
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... : Lupus (SLE), Systemic ... Sjögren Syndrome, Myositis ... #rheumatology #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... Juvenile Idiopathic Arthritis ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... anemia 4% - Myositis ... Auto-Antibodies ... : - ANA 95-100% ... autoantibodies #signs
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin ... differential #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... (20%) Renal disease ... Glomerulonephritis Myositis ... erythematosus #signs
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Antinuclear Antibody (ANA ... cytopenias) A Arthritis ... R Renal Disease ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Polyarteritis Nodosa (PAN ... ), ANCA associated ... (RA), Systemic lupus ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... - Autoimmune Rheumatologic ... • SLE • Psoriatic ... Symmetrical: • RA • SLE ... Diagnosis #MSK #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... purpura: strong sign ... ) pattern: antibodies ... SLE) • Urinalysis ... differential #diagnosis #rheumatology
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