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diagnosis differential erythematosus management syndrome systemic antibodies joint patterns vasculitis workup approach autoantibodies behcet classification laboratory mimickers monoarthritis monoarticular myelitis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Juvenile Idiopathic Arthritis ... ), Sjogren's Syndrome ... @AnnKumfer #Antinuclear ... #patterns #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
: Pathogenesis and ... like rheumatoid arthritis ... RA) or systemic lupus ... erythematosus (SLE ... ) Signs / Symptoms
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... ), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... #patterns #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... Auto-Antibodies: - ANA ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... : • Joint pain ... : • Symptoms limited
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... constitutional symptoms ... • SLE • Psoriatic ... #Diagnosis #MSK ... #rheumatology #
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... : SLE, Reactive ... Nonsurgical abdominal pain ... diagnosis #management #signs ... #symptoms #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Membranoproliferative GN ... phenomenon (16%) MSK ... Arthritis Malignancy
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... tract: Abdominal pain ... and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
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