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diagnosis classification differential sle hematology hypersensitivity reactions table algorithm ana antinuclear causes comparison pathophysiology patterns syndrome vasculitis activation allergic autoantibodies
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... Juvenile Idiopathic Arthritis ... lupus erythematosus ... lupus erythematosus ... #Antinuclear #Antibodies
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... complexes • Ex: Systemic ... Lupus Erythematosus ... , Reactive Arthritis
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... the cause: • Systemic ... Lupus • Erythematosus ... the cause: • Arthritis ... HypersensitivityReaction #Allergy
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE antibodies ... - Local and systemic ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... erythematosus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... lupus erythematosus ... lupus erythematosus ... lupus erythematosus ... ANA #patterns #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Lupus Erythematosus ... • Arthritis domain ... Highly specific antibodies ... #Lupus #Erythematosus ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... SLE-Related Auto-Antibodies ... #Lupus #Erythematosus ... #differential #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Reactive: - Systemic ... Inflammatory • Systemic ... Lupus Erythematosus ... • Rheumatoid Arthritis ... • Acne • Allergy
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... lupus erythematosus ... #Lupus #Erythematosus
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Action: IgG/lgM antibodies ... Examples: Rheumatoid arthritis ... glomerulonephritis, Systemic ... lupus erythematosus ... #allergy #table
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